Characterization of the ER-Targeted Low Affinity Ca2+ Probe D4ER

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Characterization of the ER-Targeted Low Affinity Ca2+ Probe D4ER

Calcium ion (Ca(2+)) is a ubiquitous intracellular messenger and changes in its concentration impact on nearly every aspect of cell life. Endoplasmic reticulum (ER) represents the major intracellular Ca(2+) store and the free Ca(2+) concentration ([Ca(2+)]) within its lumen ([Ca(2+)]ER) can reach levels higher than 1 mM. Several genetically-encoded ER-targeted Ca(2+) sensors have been developed...

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ژورنال

عنوان ژورنال: Sensors

سال: 2016

ISSN: 1424-8220

DOI: 10.3390/s16091419